Progesterone (oral SR)

Progesterone is a hormone produced primarily by the ovaries that plays a key role in regulating the menstrual cycle and supporting uterine tissue health. In hormone replacement therapy, bioidentical progesterone is typically paired with estradiol to support balanced endometrial signaling in women with an intact uterus. The sustained-release oral formulation is designed to provide a gradual, steady release of progesterone, which binds to progesterone receptors involved in modulating estrogen's effects on uterine tissue, as well as receptors in the brain associated with calming, sleep-related signaling. EdgeRx prescribes oral sustained-release progesterone as part of a clinician-supervised HRT protocol, typically alongside estradiol, for eligible patients based on individualized lab review.