Biest Cream

Biest cream is a compounded topical hormone formulation combining two forms of bioidentical estrogen—typically estriol and estradiol in an 80/20 ratio—delivered transdermally. Estradiol is the more potent estrogen receptor agonist, while estriol is a weaker-binding estrogen thought to have a more balanced receptor activity profile. Applied topically, biest cream is absorbed through the skin and enters circulation, where it engages estrogen receptors (ER-alpha and ER-beta) involved in bone density maintenance, vaginal and urinary tissue health, and vasomotor regulation. EdgeRx may prescribe biest cream as part of a clinician-supervised female HRT protocol, offering a transdermal delivery alternative for eligible patients based on physician assessment and lab review.