Enclomiphene

Enclomiphene is a selective estrogen receptor modulator (SERM) that works at the level of the hypothalamus, where it is designed to block estrogen's negative feedback signal on gonadotropin-releasing hormone (GnRH) secretion. This action is intended to increase downstream release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary. The resulting rise in LH and FSH is designed to stimulate the testes to increase their own natural testosterone production, offering a mechanism distinct from exogenous testosterone replacement, which can suppress natural production. EdgeRx may prescribe enclomiphene for eligible men seeking to support natural testosterone production without the testicular suppression associated with TRT, when clinically appropriate and based on lab-confirmed hormone levels.